Interrelation of reduction of mismatch negativity and cognitive deficit in paranoid schizophrenia

Authors

  • Максим Владимирович Петров Psychoneurological dispensary № 1, 39, lit. B, 12th Line of V.I., St. Petersburg, 199178, Russian Federation
  • Александр Иванович Колчев Military Medical Academy named after S.M.Kirov, 6 lit. G, Academician Lebedev st., St. Petersburg, 194044, Russian Federation
  • Борис Борисович Ершов North-West State Medical University. I.I.Mechnikova, 41, Kirochnaya st., St. Petersburg, 191015, Russian Federation
  • Антон Николаевич Гвоздецкий St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Ирина Валерьевна Голованова St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Наталья Андреевна Даева The City Psychoneurological Dispensary No. 7, 50, Staro-Petergofsky av., St. Petersburg, 190005, Russian Federation

DOI:

https://doi.org/10.21638/11701/spbu16.2017.107

Abstract

This study shows a relationship between the reduction of mismatch negativity (MMN) and the structure and severity of cognitive deficits in patients with paranoid schizophrenia. The study involved 19 patients with paranoid schizophrenia and 43 healthy subjects. The results of BACS and the psychophysiological research method of event related potentials (ERPs) found a relationship between the reduction of MMN and limited verbal working memory, reduced information processing speed and verbal fluency in patients with paranoid schizophrenia. The findings support the hypothesis posed about the importance of early information processing on the formation of cognitive deficits in patients with paranoid schizophrenia patients.

Keywords:

cognitive deficits, mismatch negativity, MMN, paranoid schizophrenia, working memory, attention, event related potentials, BACS

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Published

2017-04-25

How to Cite

Петров, М. В., Колчев, А. И., Ершов, Б. Б., Гвоздецкий, А. Н., Голованова, И. В., & Даева, Н. А. (2017). Interrelation of reduction of mismatch negativity and cognitive deficit in paranoid schizophrenia. Vestnik of Saint Petersburg University. Psychology, 7(1), 91–103. https://doi.org/10.21638/11701/spbu16.2017.107

Issue

Vol. 7 No. 1 (2017)

Section

Clinical psychology and psychophysiology

License

Articles of "Vestnik of Saint Petersburg University. Psychology" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.